WebSara Donzelli, Regina Elena National Cancer Institute, Italy. Managing Editor. Alice Castelli, Regina Elena National Cancer Institute, Italy. Editorial Board. Eiman Aleem, … Web18 gen 2024 · Here we report that loss of ncap-1, the sole C. elegans gene encoding an adaptiN Ear-binding Coat-Associated Protein (NECAP), bypasses the requirement for FCHO-1. Biochemical analyses reveal AP2 accumulates in an open, phosphorylated state in ncap-1 mutant worms, suggesting NECAPs promote the closed, inactive conformation of …
NECAPs are negative regulators of the AP2 clathrin adaptor complex
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