WebThis study demonstrated that HIF-1α-activated TMEM237 interacted with NPHP1 to activate the Pyk2/ERK pathway, thereby promoting HCC progression. Hypoxia-inducible factors … Web7 de jul. de 2024 · The p53 and HIF-1α pathways are interlinked in response to hypoxia. Our model characterizes the sensing of hypoxia, activation of p53 and HIF-1α, and decision-making in cell fates (Fig. 1). We focused on the regulation of p53 stability and activity by HIF-1 under various hypoxic conditions. More details of the model are …
Reactive Oxygen Species Generated at Mitochondrial Complex …
Web11 de abr. de 2024 · Hypoxia is one of the major causes of cancer resistance and metastasis. Currently, it is still lack of convenient ways to simulate the in vivo hypoxic … Web1 de abr. de 1998 · In pursuing the mechanism of oxygen sensing, a great deal of attention has been turned towards analysis of the mechanism of activation of HIF-1. In keeping with the demonstration of HIF-1 DNA-binding activity in a wide variety of cell types, mRNAs for HIF-1α and HIF-1β have been found in all cells and tissues examined ( Wenger et al . … pagel rheumatologie
Hypoxia-inducible factor-1α induces multidrug resistance protein …
WebIntratumoral hypoxia induces the HIF-1-dependent expression of the chemokine CCL28, which recruits regulatory T cells that promote tumor tolerance as well as angiogenesis . … WebThere are numerous reports that melatonin inhibits the hypoxia-inducible factor, HIF-1α, and the HIF-1α-inducible gene, VEGF, both in vivo and in vitro. Through the inhibition of … Web1 de nov. de 2024 · Proinflammatory cytokines (TNF-α and IL-1β) can upregulate HIF-1α, by a mechanism that inhibits PHD enzymes with stabilization of HIF activity; conversely, HIF-1 transcriptional activity can downregulate receptors for inflammatory cytokines, attenuating the neuroinflammation (Dehne and Brune, 2009; Xing and Lu, 2016; Iyalomhe et al., 2024). pagel rb 50