WebJul 5, 1995 · Ammonium ion concentrations ranging from 0 to 10 mM are shown to significantly reduce the sialylation of granuiocyte colony-stimulating factor (G-CSF) produced by recombinant Chinese hamster ovary cells. Specifically, the degree of completion of the final reaction in the O-linked glycosylation pathw … WebThe cytokines granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are members of a family of hematopoietic growth …

Research Article Granulocyte colony stimulating factor …

WebMar 16, 1998 · The ovarian adenocarcinoma cell line HEY was used as an in vitro model to study the influence of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on epithelial tumours such as ovarian cancer. Serum-starved cells were treated with rhG-CSF in a time- and dose-dependent manner. Cell pr … WebTwo forms of recombinant human G-CSF (rhG-CSF) are available for clinical use: filgrastim is expressed in E coli and non-glycosylated, whereas lenograstim is derived from Chinese hamster ovary (CHO) cells and glycosylated. The function of the sugar chain, accounting for approximately 4% of the molec … buy prime rib

Granulocyte colony-stimulating factor

WebDec 1, 2002 · Since granulocytes are one of the major leukocytes, we focused our attention on the presence and local production of granulocyte colony-stimulating factor (G-CSF) in … Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Functionally, it is a cytokine and hormone, a type of colony … See more G-CSF is produced by endothelium, macrophages, and a number of other immune cells. The natural human glycoprotein exists in two forms, a 174- and 177-amino-acid-long protein of molecular weight … See more The gene for G-CSF is located on chromosome 17, locus q11.2-q12. Nagata et al. found that the GCSF gene has 4 introns, and that 2 different polypeptides are synthesized … See more The skin disease Sweet's syndrome is a known side effect of using this drug. See more The recombinant human G-CSF (rhG-CSF) synthesised in an E. coli expression system is called filgrastim. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. Filgrastim was first … See more Chemotherapy-induced neutropenia Chemotherapy can cause myelosuppression and unacceptably low levels of white blood cells (leukopenia), making patients … See more Mouse granulocyte-colony stimulating factor (G-CSF) was first recognised and purified in Walter and Eliza Hall Institute, Australia in … See more • PEGylation See more WebNov 1, 2010 · SAA may induce the adhesion and migration of ovarian tumor cells as it does for human leukocytes (Badolato et al. 1994; Xu et al. 1995) and enhance tumor cell proliferation, survival, and angiogenesis as has been shown in relevance to rheumatoid arthritis (Lee et al. 2006; Mullan et al. 2006). buy primrose seeds