WebApr 12, 2024 · 1 INTRODUCTION. Gigaxonin is a ubiquitously expressed protein encoded by the GAN gene located on human chromosome 16q24.1. 1, 2 The lack or loss of function of gigaxonin causes giant axonal neuropathy (GAN), an autosomal recessive disorder. The GAN gene has more than 50 distinct loss of function mutations that cause the disorder. 3 … WebJan 24, 2024 · Motor-dependent motion along actin and microtubules (MTs) sustains the intracellular organization of many cell types, and is particularly relevant to polarized …
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WebMay 24, 2024 · Microtubule fundamentals. Microtubules are intrinsically polarized filaments formed from the polymerization of tubulin heterodimers; each heterodimer is an obligate dimer of one α-tubulin protein and one β-tubulin protein (Figure 1 A).Heterodimers assemble head-to-tail to form longitudinal chains called protofilaments, and lateral interactions … WebJan 1, 2010 · The cytoskeleton carries out three broad functions: it spatially organizes the contents of the cell; it connects the cell physically and biochemically to the external environment; and it generates coordinated forces that enable the … WebMicrotubule cytoskeletal polymers play crucial roles during the various processes of neurodevelopment, such as cell division, dendrite arborization, axon specification, synapse formation, intracellular transport, and axon guidance/maintenance. ... and that hyperactivated or disrupted molecular motor activities may be similarly implicated in ... biting side of tongue in sleep